Welcome to our new lab member Jenny Guan!

Oct 09, 2025 - Welcome to our new lab member Jenny Guan!
Jenny is originally from Nanjing, China, and earned her bachelor’s degree from the University of Michigan, Ann Arbor (Go Blue!) in 2024. She's interested in developing treatments for established TNBC metastasis, focusing on the tumor microenvironment. She is a Ph.D. student in the Cancer & Cell Biology (CCB) program and joined the Zhang lab in 2025, co-mentored by Dr. Jeffrey Rosen. 

Fatty acids promote immune suppression and therapy resistance in triple negative breast cancer

Apr 02, 2025 - Fatty acids promote immune suppression and therapy resistance in triple negative breast cancer

A new study published in the journal Immunity reveals a mechanism that allows triple negative breast cancer (TNBC) to develop resistance to therapy. Researchers at Baylor College of Medicine showed that lipid accumulation in tumor cells and nearby immune cells promotes immune suppression, but disrupting lipid formulation reverses treatment resistance and the immunosuppressive microenvironment.  (BCM News - read more)

Triple-Negative Breast Cancer Therapy Resistance Due to Lipid Accumulation in Cells

Apr 02, 2025 - Triple-Negative Breast Cancer Therapy Resistance Due to Lipid Accumulation in Cells

A preclinical study by researchers at Baylor College of Medicine has uncovered a mechanism that allows triple-negative breast cancer (TNBC) to develop resistance to immune checkpoint blockade (ICB) immunotherapy and to chemotherapy. The study, including tests in mouse models, showed that lipid accumulation in tumor cells and nearby immune cells promotes immune suppression.  (GenEng News - read more)

BCM News Article!

Sep 17, 2024 - BCM News Article!

Our lab at Baylor College of Medicine and collaborating institutions have discovered new insights into tumor-induced B cell changes in blood and bone marrow of triple negative breast cancer patients. The findings, published in Nature Cell Biology, show two distinct patterns of B cell abnormalities that could serve as blood biomarkers for determining likelihood of response to standard-of-care chemotherapy and immunotherapy. (BCM News - read more)

Welcome to our new lab member Michael Dieffenbach!

Mar 18, 2024 - Welcome to our new lab member Michael Dieffenbach!

Mike graduated from the School of Biomedical Sciences at the University of Central Florida. He is interested in breast cancer metastasis and identifying new biomarkers and therapies for TNBC. He joined Zhang Lab in 2024 and is currently a M.D./Ph.D. student in the DDMT program.

Welcome to our new lab member Noa Peled!

Mar 04, 2024 - Welcome to our new lab member Noa Peled!
Noa graduated from Avram and Stella Goldstein-Goren Department of Biotechnology Engineering at Ben Gurion University of the Negev, Israel. She is interested in studying breast cancer bone metastases and aims to develop new therapeutic strategies against bone metastasis. She joined Zhang Lab in 2024 as a postdoctoral researcher.

Welcome to our new lab member Xuan Li!

Mar 01, 2024 - Welcome to our new lab member Xuan Li!
Xuan graduated from the School of Life Sciences at Tsinghua University, China in 2023. She is interested in the metastasis of ER-positive breast cancer. Welcome Xuan Li to join Zhang Lab as a postdoctoral researcher.